The antioxidant and hepatoprotective action is presently attributed primarily to the flavonolignan silybin, whose lack of water solubility results in a pronounced enterohepatic recirculation providing significant liver exposure over time. 3,5 g) Droge. Silybum marianum (milk thistle) and its derivatives have been used for centuries for the treatment of liver disease. Few adverse effects have been noted.161–169, Alexander J. German, ... Grant Guilford, in Small Animal Clinical Pharmacology (Second Edition), 2008. Continue Reading. This idiosyncratic reaction to milk thistle seems to be a rarity. Silymarin acts as an antioxidant by reducing free radical production and lipid peroxidation. Milk thistle (Silybum marianum L. [4][6] It is possibly native near the coast of southeast England. Milk thistle is taken for its beneficial properties in treating hepatitis and liver cirrhosis. A brief report on S. marianum with special emphasis on silymarin is outlined in this chapter. Cindy X. Cai, ... Shobha Castelino-Prabhu, in Dietary Interventions in Liver Disease, 2019. Milk thistle (Silybum marianum) is an herbal supplement used to treat liver and biliary disorders. By continuing you agree to the use of cookies. There are no reported absolute contraindications for silymarin and this drug is well tolerated by the oral route. Herkunft, Pflege/Ansprüche und andere Eigenschaften dieser Pflanzen für den Garten, Bilder, Fotos. I currently use it everyday. PubMed:Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil. Do not use more than prescribed dose. The plant can grow as tall as 10 feet, with broad, … or Milk thistle is a medicinal plant native to Northern Africa, Southern Europe, Southern Russia and Anatolia. The dried solvent extract is known as silymarin, and, until the advent of HPLC, was assayed in its entirety by UV spectroscopy directly or by colorimetric techniques after reaction with dinitrophenylhydrazine. Similar to what was seen in healthy volunteers, milk thistle had a nonsignificant effect on darunavir AUC and Cmin. The main active components of milk thistle, collectively known as silymarin, consist of a mixture of flavonoids that are present in the fruits, seeds, and leaves of the plant [27]. Overdoses rarely cause significant morbidity. Milk thistle has also been shown to act as an insulin sensitizer in studies of patients with NAFLD.171, Give 420 to 600 mg/day (standardized to contain 70%–80% silymarin).172,173, Exercise caution in patients taking drugs metabolized by cytochrome, the P-450 isoenzymes CYP3A4 and CYP2C9, because the silibinin content of milk thistle may inhibit these hepatic isoenzymes.174, Alex C. Chin, Leland B. Baskin, in Therapeutic Drug Monitoring, 2012. This salt may also be used for purposes not listed in this medication guide. Description. Few adverse effects have been noted.161–169, Alexander J. German, ... Grant Guilford, in Small Animal Clinical Pharmacology (Second Edition), 2008. In practice, even the best commercial ‘silymarin’ standards contain only 60% of total flavanones, which gives significant discrepancies where suppliers are using older colorimetric methods; the summed HPLC data tends to give a much lower value. EXTRACT OF LADY'S THISTLE FRUIT, EXTRACT OF SILYBUM MARIANUM FRUIT, LADY'S THISTLE (SILYBUM MARIANUM) FRUIT EXTRACT, LADY'S THISTLE FRUIT EXTRACT, SILYBUM MARIANUM (LADY'S THISTLE) FRUIT EXTRACT, and SILYBUM MARIANUM FRUIT EXTRACT . Dissolution of the sample extract (and of the standards) requires methanol as solvent and a significant period of ultrasonic treatment to ensure complete solubility of the flavones. Silymarin has been traditionally used in the treatment of liver disease but while it has recently been advocated for use in pets, all scientific information available concerns human use. The business intelligence report on the various growth dynamics of the Silybum marianum market helps interested market participants to chart possible evolution trajectories during the forecast period. Active ingredients of milk thistle seeds are found in silymarin, which is a mixture of the flavolignans silibinin (silybin), isosilibilin, silichristin and silidianin. This idiosyncratic reaction to milk thistle seems to be a rarity. It is a flowering plant that comes from the same family of plants as the daisy. Milk thistle ( Silybum marianum ) has been used for centuries as a medicinal plant; according to folk tradition, its characteristic violet flowers and white-veined leaves came from the Virgin Mary’s milk .It is native to the Mediterranean and a member of Asteraceae family, which also … The common name, milk thistle, is derived from the milky-white veins on the leaves, which, when broken open, yield a milky sap. This review focuses exclusively on published literature pertaining to the potential use of Silybum marianum or its derivatives for the treatment of alcoholic liver disease. The whole plant is astringent, bitter, cholagogue, … Silybum marianum has other common names including cardus marianus, milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium). Apple A. Bodemer MD, in Integrative Medicine (Fourth Edition), 2018, Although milk thistle has not been suggested to play a role in psoriasis treatment, this botanical has been purported to protect against methotrexate-induced hepatotoxicity. A thorough check-up showed no abnormalities. Standards of the individual components can be purchased but are expensive; hence, as with Echinacea, these can be used on a one-time basis as primary standards to establish relative retention times. Family: Asteraceae Part used: Fruit/Seed Constituents: Flavolignans (silymarin complex), flavonoids, volatile oil, bitter principle, mucilage Actions: Cholagogue, hepatic, hepatoprotective & hepatorestorative, galactagogue, demulcent Medical uses: Research has shown that it promotes the regeneration of diseased liver cells and protects them … In regard to cellular drug transport, silibinin did not alter P-gp mediated efflux of ritonavir in intestinal epithelial cells [142]. In a similar manner, separate clinical studies reported no effects on indinavir plasma levels after administration of silymarin for 14 days [220] or 28 days [221] in healthy individuals. Silymarin, a mixture of flavanoid complexes, is the active component that protects liver and kidney cells from toxic effects of drugs, including chemotherapy. 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